Make a mess of, destroy or ruin. Synonyms: ball up, blow, bobble, bodge, bollix, bollix up, bollocks, bollocks up, botch, botch up, bumble, bungle, flub, fluff, foul up, fuck up, fumble, louse up, mess up, muck up, muff, screw up, spoil. "The pianist screwed up the difficult passage in the second movement"
