The greatest work or achievement of a particular artist, writer, or other individual. "Inspired by this milieu, (Max Stirner) wrote his magnum opus The Ego and Its Own, which was published in November 1844."
... is a crushing blow," said the old man. "That is my MAGNUM OPUS—the pile of papers on the side table yonder. It is my analysis of the documents found in the Coptic monasteries of Syria and Egypt, a work which will cut deep at the very foundation of revealed religion. With my enfeebled health I do not know whether I shall ever be able ... — The Return of Sherlock Holmes • Arthur Conan Doyle
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